A dietary supplement combining folic acid, vitamin B6, and vitamin B12 failed to reduce the risk for cardiovascular events among women at risk for or with a history of cardiovascular disease (CVD), randomized trial data show.

"These null results for women are consistent with those previously reported in randomized trials composed primarily of men with pre-existing vascular disease," say the researchers, led by Christine Albert (Brigham and Women's Hospital, Boston, Massachusetts, USA).

Despite the observed link between hyperhomocysteinemia and increased CVD risk, previous randomized trials have ...

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