| FULLTEXT: -LIPIDS: -The association between serum levels of oxLDL-lgG and oxLDL-lgM autoantibody with adult acute myeloblastic leukaemia |
Abstract & Aim
To evaluate the relationship between serum antibodies against ox-LDL levels and adult acute myeloblastic leukemia (AML). Methods
Forty three patients with AML and 52 normal controls were enrolled in this study in the Department of Hematology, Tumor Center of Qilu Hospital of Shandong University from Feb. 2008 to Mar.2009.
Serum lgG and lgM antibodies versus the oxLDL levels were evaluated by ELISA method. Data was analyzed by covariance and binary Logistic regression.
Results
Serum mean levels of oxLDL-lgG in patients (38.92 ± 21.1259 ug/ml) were significantly lower than in control subjects (78.88 ± 9.3705 ug/ml);
Meanwhile, Serum mean levels of oxLDL-lgM in patients (20.53 ± 10.2990 IU/L) were significantly higher than in control subjects (10.29 ± 10.5771 IU/L).
Binary logistic regression showed the odds ratios of association of oxLD-lgG and oxLD-lgM with adult AML were 0.72(95%CI: 0.55-0.94) and 1.11(95%CI: 1.01-1.21) respectively after adjusted for potential confounders.
Conclusion
In the preliminary investigation we found a descensive oxLDL- lgG and an elevated oxLDL-lgM serum levels for the adult AML. Future studies need to confirm the hypothesis whether they related to the development and progression of adult AML.
More than two decades ago, epidemiological studies showed a U-shaped relationship between total cholesterol (TC) levels and risk of all-cause mortality.
The relationship between the baseline serum cholesterol level to total mortality was attributed to the high number of deaths associated with serum cholesterol level at the high end of the distribution (mainly due to coronary heart disease) and at the low end (mainly due to cancer) [1-3].
Recent studies showed that, as an endocrine organ, adipose tissue plays an important role in regulating energy metabolism and inflammation.
It has also been associated with several cancers. Some studies have shown that adiponectin (ADP), Serum immunoglobulin G and immunoglobulin M antibodies versus the oxLDL levels (oxLDL-lgG, oxLDL-lgM) may play a role in the development and progression of various types of malignancies [4-6].
Moreover, there is no single published study with information on the serum levels of oxLDL-lgG and oxLDL-lgM for the patients with adult acute myeloblastic leukemia (AML).
We made a primary study to evaluate the association of oxLD-lgG or oxLD-lgM with adult AML.
Recent studies showed that, as an endocrine organ, adipose tissue plays an important role in regulating energy metabolism and inflammation. It has also been associated with several cancers.
Some studies have shown that adiponectin (ADP), Serum immunoglobulin G and immunoglobulin M antibodies versus the oxLDL levels (oxLDL-lgG, oxLDL-lgM) may play a role in the development and progression of various types of malignancies [4-6].
Moreover, there is no single published study with information on the serum levels of oxLDL-lgG and oxLDL-lgM for the patients with adult acute myeloblastic leukemia (AML).
We made a primary study to evaluate the association of oxLD-lgG or oxLD-lgM with adult AML. Lipids Health Dis. 2010; 9: 11. doi: 10.1186/1476-511X-9-11 Hao Li, 1Tumor Center of Qilu Hospital, Shandong University, Jinan, PR China 2College of Public Health, Shandong University, Jinan, PR China 3Institutes of Basic Medicine, Shandong Academy of Medical Sciences Jinan, PR China 4College of economics, Shandong University, Jinan, PR China 5Feicheng County People's Hospital, Feicheng, PR China
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NOTICIA SELECCIONADA POR E-MEDICUM |
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#1 Yu Tao Diao,#2 Hui Qing Li,3 Qing Ma,3 Jia Cui,3 Ying Zhi Zhou,4 and Dong Li5 
Director Médico